Our Publications and Research

PLxGuard™ drug delivery platform has consistently demonstrated the potential to improve delivery and absorption of essential drugs currently on the market, and to reduce the risk of local gastrointestinal (GI) injury.

Papers

Pharmacokinetic and pharmacodynamic profile of a novel phospholipid aspirin formulation. Angiolillo DJ, et al. Clin Pharmacokinet. 2022:1-15. Published online January 20, 2022. doi:10.1007/s40262-021-01090-2.

Influence of lipid excipients on platelet function and the pharmacodynamic effects of aspirin.
Schneider DJ, et al. J Cardiovasc Pharmacol. 2021;78(2):297-301.

Antitumor and antiangiogenic effects of aspirin-PC in ovarian cancer.
Huang Y, et al. Mol Cancer Ther. 2016;15(12):2894-2904.

Posters/Abstracts

Impact of sex on platelet inhibition by aspirin in obese patients with type 2 diabetes: a pooled, patient-level analysis of two randomized clinical trials.
Kimmelstiel C, et al. Abstract accepted at: EuroPCR; May 19-22, 2020. Conference cancelled due to COVID.

Improved pharmacologic profile of a novel, liquid aspirin formulation compared with enteric-coated aspirin: a pooled, patient level analysis of two randomized crossover studies.
Bhatt DL, et al. Poster presented at: American College of Cardiology’s 69th Annual Scientific Session & Expo; March 28-30, 2020; Chicago, IL.

Impact of weight on the antiplatelet effects of aspirin: results of a pooled analysis of two randomized crossover studies comparing a liquid aspirin formulation with enteric-coated aspirin.
Bhatt DL, et al. Poster presented at: American College of Cardiology’s 69th Annual Scientific Session & Expo; March 28-30, 2020; Chicago, IL.

Bioavailability of aspirin in fasted and fed states of a novel pharmaceutical lipid aspirin complex formulation.
Angiolillo DJ, et al. Poster presented at: International Stroke Congress (ISC); February 18-21, 2020; Los Angeles, CA.

Pharmacokinetic and pharmacodynamic assessment of a lipid-based aspirin formulation: results of a prospective, randomized, crossover study.
Angiolillo DJ, et al. Poster presented at: European Society of Cardiology Congress (ESC); August 31-September 4, 2019; Paris, France.